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Unmatched Inertness & Durability

Try an InertSustain™ HPLC Column for Free

GL Sciences newly developed technologies has enabled the modification of pore size, and its homogeneity, along with the amount of silanol groups of the base silica to be adequately controlled for each ligand in a variety of phases and applications.


This evolved surface silica (ES Silica) allows GL Sciences InertSustain™ Series to have a wide portfolio with extremely inert, chemical sustainability and batch to batch reproducibility for state-of-the-art analysis.


While other columns show poor peak shape, insufficient separation efficiency often with secondary interactions, and unsuitable physical properties of base silica that result in poor reproducibility.

Highly end-capped ODS column such as InertSustain C18 column offers an opportunity to flush out contaminants from the column surface easily using an organic solvent. Coffee melanoidins are brown heterogeneous polymers contained in coffee. Its components are not clarified yet, but it is considered to contain several ionic compounds, which a poorly end-capped column will adsorb those ionic compounds leading to short column lifetime.


As for ODS column, which is commonly used for HPLC and LC/MS/MS, its inertness has an influence not only on peak shape but also detection sensitivity and durability. It is highly recommended to use highly end-capped column which provides good peak shape for both basic and acidic compounds such as InertSustain C18 column.


Quality and Performance of InertSustain™ C18 Column

To maintain precise product reproducibility, strict chromatographic tests for inertness, durability, theoretical plates and reproducibility of retention time are employed.

Basic Compounds

InertSustain C18 Column

Basic Compound InertSustain C18.jpg

X Select CSH C18

Basic Compound X-Select.jpg

ZORBAX Eclipse Plus C18

Zorbax  Basic Compound.jpg
Conditions - Basic Compound.jpg

Acidic Compounds

InertSustain C18


X Select CSH C18


ZORBAX Eclipse Plus C18


Chelating Compound

InertSustain C18


X Select CSH


Extremely Low Operating Back Pressure

Due to the introduction of Evolved Surface Silica, InertSustain C18 offers a signifi cantly lower operating back pressure without sacrificing efficiency. As shown below, InertSustain C18 produces the lowest back pressure than other brands columns in the industry.


HPLC Columns:


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Reliable Reproducibility, Performance and Quality

Rigorous quality control of physical properties and strict chromatographic tests for inertness and selectivity, contribute to the production of InertSustain C18 with an outstanding reproducibility and long column lifetime.


Superior peak shape with highly

reproducible chromatograms can

be obtained even for those strong basic compounds.


Reliable reproducibility and

same retention behavior between various particle size columns


© 2020 GlSciences Inc.. All rights reserved.