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Unmatched Inertness & Durability

C18 Column

Reversed Phase Column

Tailing of peaks or adsorption of peaks can be experienced when a C18 column has residual adsorption sites. Such phenomenon would not be observed on InertSustain as the silanols are completely end-capped, having a neutral silica surface.

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HPLC Columns:


C18 Column Benefits:

Quality & Performance of InertSustain™ C18 Column Comparisons :

Experience The InertSustain™ (Inertness & Sustainability)

Highly end-capped ODS column such as InertSustain C18 column offers an opportunity to flush out contaminants from the column surface easily using an organic solvent. Coffee melanoidins are brown heterogeneous polymers contained in coffee. Its components are not clarified yet, but it is considered to contain several ionic compounds, which a poorly end-capped column will adsorb those ionic compounds leading to short column lifetime.


As for ODS column, which is commonly used for HPLC and LC/MS/MS, its inertness has an influence not only on peak shape but also detection sensitivity and durability. It is highly recommended to use highly end-capped column which provides good peak shape for both basic and acidic compounds such as InertSustain C18 column.

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Quality and Performance of InertSustain™ C18 Column

To maintain precise product reproducibility, strict chromatographic tests for inertness, durability, theoretical plates and reproducibility of retention time are employed.

Basic Compounds

InertSustain C18 Column

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X Select CSH C18

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ZORBAX Eclipse Plus C18

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Acidic Compounds

InertSustain C18


X Select CSH C18


ZORBAX Eclipse Plus C18


Chelating Compound

InertSustain C18


X Select CSH


Wide pH compatability with Long Column Lifetime

As shown in the experiment below, due to the introduction of Evolved Surface Silica, InertSustain C18 maintained high effi ciency and peak shape for 300 hours while other “wide pH” column brands failed.


Extremely Low Operating Back Pressure

Due to the introduction of Evolved Surface Silica, InertSustain C18 offers a signifi cantly lower operating back pressure without sacrificing efficiency. As shown below, InertSustain C18 produces the lowest back pressure than other brands columns in the industry.


HPLC Columns:


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Reliable Reproducibility, Performance and Quality

Rigorous quality control of physical properties and strict chromatographic tests for inertness and selectivity, contribute to the production of InertSustain C18 with an outstanding reproducibility and long column lifetime.


Superior peak shape with highly

reproducible chromatograms can

be obtained even for those strong basic compounds.


Reliable reproducibility and

same retention behavior between various particle size columns


Ordering Guide

© 2020 GlSciences Inc.. All rights reserved.