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Unmatched Inertness & Durability

Inertness & Durability combined in a new HPLC Column

Generally, silica based columns are mechanically stable and provide high efficiencies, however, they cannot be used under alkaline conditions and their residual silanol groups tend to adsorb organic bases.


InertSustain employs a radically new type of silica, in which the surface of the silica is uniquely modified, enabling precise control of the silica properties. InertSustain inherits the advantages of all the current Inertsil HPLC columns (e.g., extremely low operating back pressure, superior inertness to typically any analytes, high efficiency and compatibility with a wide range of solvents), but now can be used for wide pH analysis with consistent performance from column to column and lot to lot.

HPLC Columns :


1st Stage [Synthesis of “Evolved Surface Silica”]

It is not possible to end-cap 100 % of residual silanols using traditional chemical modification procedures. GL Sciences studied the possibility of developing a radically new type of silica, a silica that would provide both high inertness (base deactivation) and durability at a wide range of pH.

2nd Stage [Chemical Bonding of ODS group]

The introduction of Evolved Surface Silica and our cutting-edge chemical bonding technology make InertSustain compatible with 100 % aqueous mobile phases, while maintaining strong non-polar retentivity

3rd Stage [Complete End-capping]

GL Sciences’ complete end-capping technology allows InertSustain to provide high efficiency and superior peak shape even to those well-known strong adsorptive analytes.

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Radically New Silica Gel

InertSustain Series

Developing a new method is a time-consuming operation. On top of this selecting an HPLC column plays a major role to achieve the desired separation for your critical analysis.


The InertSustain series are offered with C18, C8, Phenyl and Aminopropyl phases, which cover an extended range of selectivity with extremely inert packing materials to answer your diffi cult method development.

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